Study on Spontaneous Combustion "Three Zones" of the Distribution Law and Integrated Fire Prevention Technology in Mined-Out Area of Lingquan Mine.

To determine the risk range of remaining coal in the goaf of the higher slice on the seventh mining and fifth face of Lingquan Mine, the beam tube monitoring system was adopted to supervise the temperature and gas content changes in the goaf during the normal mining period of the working face. As per the principle of dividing spontaneous combustion "three zones" (SCTZ), numerical simulation of the distribution of SCTZ in the goaf of the work face was performed. The O2 content and index gas in the goaf were measured and analyzed, and combined with the in-situ measurement outcomes, the distribution of SCTZ in the goaf was determined through the FLUENT numerical modeling program. The outcomes show that the distribution pattern of SCTZ in the goaf of fully mechanized mining face is: the heat dissipation zone is 0-41 m, the oxidation zone is 41-97 m, the suffocation zone is more than 97 m away from the work face, and the increment of temperature is 0.7/°C. Based on the judgement result of SCTZ, the minimum recovery rate of work face is above 3.7 m/d. The use of new polymer materials validly solves the problem of excessive CO in the return air corner of the goaf and prevents self-ignition accidents in the goaf.

Mass Production of 3D Connective Graphene Networks by Fluidized Bed Chemical Vapor Deposition and Its Application in High Performance Lithium-Sulfur Battery.

Three-dimensional (3D) graphene with novel nano-architectures exhibits many excellent properties and is promising for energy storage and conversion applications. Herein, a new strategy based on the fluidized bed chemical vapor deposition (FB-CVD) process was proposed to prepare 3D graphene networks (3DGNs) with various nano-architectures. Specially designed SiC-C@graphene core/shell nanoparticles were prepared taking the advantages of the FB-CVD system, and 3DGNs with hierarchical nanostructures were obtained after removing the SiC core. The 3DGNs performed well as electrodes of lithium-sulfur batteries. The C-S cathode showed good rate performance at the current density of 0.1-2.0 C, and an initial discharge capacity of 790 mAhg-1 cathode was achieved at a current density of 0.2 C. The Li-S batteries showed stabilized coulombic efficiency as high as 94% and excellent cyclic performance with an ultra low cyclic fading rate of 0.075% for the initial 280 cycles at a current density of 1.0 C. The improved electrochemical performance was ascribed to the enhanced conductivity by the connective graphene networks and the weakened shuttle effect by the special outer graphene layers. Mass production of the products was realized by the continuous FB-CVD process, which opens up new perspectives for large scale application of 3D graphene materials.

Bioinspired nanoplatelets for chemo-photothermal therapy of breast cancer metastasis inhibition.

Breast cancer is associated with high mortality due to tumor metastasis. The anti-metastasis efficacy of photochemotherapy is strictly limited by poor targeting capability with respect to circulating tumor cells (CTCs) in blood and lymph. Herein, we decorate the platelet membrane (PM) on a surface of nanoparticles (NPs), referred to as nanoplatelets. A chemotherapeutic drug, doxorubicin (DOX), and an FDA-approved photothermal agent, indocyanine green (ICG), are co-encapsulated into the biomimetic nanoplatelets. Nanoplatelets possess immune surveillance-escaping capability and specifically capture and clear CTCs in both blood and lymphatic circulations via high-affinity interactions between the P-Selectin of PM and CD44 receptors of tumor cells. PM-coated NPs show greater cellular uptake in MDA-MB-231 breast cancer cells and further elicit higher cytotoxicity to tumor cells relative to uncoated NPs. In vivo, we disclose that the multifunctional nanoplatelets not only completely ablate the primary tumor but also inhibit breast cancer metastasis with high efficiency in the three established xenograft or orthotopic breast tumor-bearing mice models. We conclude that such biomimetic nanoplatelets represent a promising strategy of coating a surface of nanoparticles with platelet membrane to actively capture and destroy CTCs in blood and lymph in breast cancer anti-metastasis therapy.

The On-Off chiral mesoporous silica nanoparticles for delivering achiral drug in chiral environment.

In the current stage, the On-Off mechanism of chiral mesoporous silica nanoparticles (CMSN) for delivering achiral drug in chiral environment has rarely been reported. Herein, On-Off chiral mesoporous silica nanoparticles (On-Off-D-CMSN and On-Off-L-CMSN) were successfully synthesized and its particular contribution in delivering achiral drug indometacin (IMC) in chiral environment was mainly studied. The as-synthesized On-Off-D-CMSN and On-Off-L-CMSN were verified by fourier transform infrared spectrometer and circular dichroism. The transmission electron microscope test and nitrogen adsorption/desorption analysis showed that On-Off-D-CMSN and On-Off-L-CMSN were regular spheres with concealed pore channels. The zeta potential analysis demonstrated that the grafting functional groups distributed on the inner and outer surfaces of On-Off-D-CMSN and On-Off-L-CMSN. Through dissolution experiment, the drug release of IMC loaded On-Off-D-CMSN (84%) and IMC loaded On-Off-L-CMSN (70%) were about 2.4 and 2.0 times higher than pure IMC (35%) in pH 6.8 phosphate buffer solution (PBS), respectively. IMC loaded On-Off-D-CMSN and IMC loaded On-Off-L-CMSN exerted different chiral recognition functions with On-Off mechanism in in-vitro chiral environment (pH 6.8 PBS-L and pH 6.8 PBS-D). The results of anti-inflammation pharmacodynamics further demonstrated that On-Off-D-CMSN and On-Off-L-CMSN can trigger chiral biological environment to achieve on or off chiral recognition functions. The unique advantages of On-Off chiral mesoporous silica nanoparticles in triggering chiral biological environment can provide valuable instruction for designing drug delivery system.